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Zaira Ianniello Melissa Sorci Lavinia Ceci Ginistrelli Alessia Iaiza Marcella Marchioni Claudia Tito Ernestina Capuano Silvia Masciarelli Tiziana Ottone Cristina Attrotto Manuela Rizzo Luca Franceschini Stefano de Pretis Maria Teresa Voso Mattia Pelizzola Francesco Fazi Alessandro Fatica 《Cell death & disease》2021,12(10)
994.
Cristina G. Di Camillo Carlo Cerrano Tiziana Romagnoli Barbara Calcinai 《Symbiosis (Philadelphia, Pa.)》2017,71(3):185-198
The relationships between sponges and macroalgae have been poorly investigated, especially in temperate waters. This work describes the consortium between the dictyoceratid sponge Dysidea pallescens and the red alga Acrochaetium spongicola permeating spongin fibres in the Mediterranean Sea; moreover, this is the first report of a diatom, Amphora pediculus, living also inside the spongin skeleton. The annual trend of the total algal biomass did not vary over time in relation to the temperature, irradiance and incorporation of foreign bodies. Our analyses, conducted by light and electron microscopy, suggest that both the macroalga and the diatom invade the skeleton of the sponge from the external environment, and that the benthic diatom, epiphyte of the macroalga, is passively carried inside the fibres through the growth of Acrochaetium spongicola. All the examined samples of D. pallescens showed that the macroalga permeated at least some fibres, while the presence of the diatom was occasional. The superficial layer of the sponge, thin and reticulate, likely allows the passage of the light and ensures the algal survival inside the sponge tissue. The high occurrence of the association with A. spongicola, together with the morphological adaptations of the sponge favouring the algal life, suggest that the relationship is mutualistic. The possible benefits for the involved partners are hypothesized. The taxonomy and ecology of endozoic Acrochaetiales are controversial due to the reduced size of thalli, the absence of peculiar diagnostic characters and unknown reproductive structures. Therefore, detailed studies on the relationships between the algae and their hosts will provide helpful information for the algal identification. 相似文献
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SRC Family Kinase Inhibition in Ewing Sarcoma Cells Induces p38 MAP Kinase‐Mediated Cytotoxicity and Reduces Cell Migration 下载免费PDF全文
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Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha‐galactosidase A (GLA) enzymes 下载免费PDF全文
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Marine Melixetian Daniela Bossi Marija Mihailovich Simona Punzi Iros Barozzi Federica Marocchi Alessandro Cuomo Tiziana Bonaldi Giuseppe Testa JeanChristophe Marine Eleonora Leucci Saverio Minucci Pier Giuseppe Pelicci Luisa Lanfrancone 《EMBO reports》2021,22(3)
Transition from proliferative‐to‐invasive phenotypes promotes metastasis and therapy resistance in melanoma. Reversion of the invasive phenotype, however, is challenged by the poor understanding of mechanisms underlying its maintenance. Here, we report that the lncRNA TINCR is down‐regulated in metastatic melanoma and its silencing increases the expression levels of invasive markers, in vitro migration, in vivo tumor growth, and resistance to BRAF and MEK inhibitors. The critical mediator is ATF4, a central player of the integrated stress response (ISR), which is activated in TINCR‐depleted cells in the absence of starvation and eIF2α phosphorylation. TINCR depletion increases global protein synthesis and induces translational reprogramming, leading to increased translation of mRNAs encoding ATF4 and other ISR proteins. Strikingly, re‐expression of TINCR in metastatic melanoma suppresses the invasive phenotype, reduces numbers of tumor‐initiating cells and metastasis formation, and increases drug sensitivity. Mechanistically, TINCR interacts with mRNAs associated with the invasive phenotype, including ATF4, preventing their binding to ribosomes. Thus, TINCR is a suppressor of the melanoma invasive phenotype, which functions in nutrient‐rich conditions by repressing translation of selected ISR RNAs. 相似文献
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Carmen Di Franco Elena Beccari Tiziana Santini Giuseppe Pisaneschi Giorgio Tecce 《BMC microbiology》2002,2(1):33-15
Background
Bacillus mycoides Flügge, a Gram-positive, non-motile soil bacterium assigned to Bacillus cereus group, grows on agar as chains of cells linked end to end, forming radial filaments curving clock- or counter-clockwise (SIN or DX morphotypes). The molecular mechanism causing asymmetric curving is not known: our working hypothesis considers regulation of filamentous growth as the prerequisite for these morphotypes. 相似文献1000.